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(A) Loading efficiency (LE%) and encapsulating efficiency (EE%) of SIM@HA-MSN (n = 3). (B) XRD spectrum and (C) DSC analysis of bare MSN, SIM, and SIM@HA-MSN. (D) In vitro drug release of free SIM, SIM@MSN, and SIM@HA-MSN in the presence or absence of HAase (100 U/mL) (n = 3).
