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. 2021 Dec 6;89(3):135–145. doi: 10.1159/000520281

Fig. 2.

Fig. 2

Emodin inhibited levels of inflammatory factors and activated BDNF/TrkB signaling in SAE mice. a Pro-inflammatory factors of IL-1β, IL-6, TNF-α, and anti-inflammatory factors of IL-10, IL-4, and TGF-β were measured by ELISA in different groups of mice. b Protein levels of TrkB, p-TrkB, and BDNF were evaluated by Western blotting in different mice groups. Each group had 6 mice. All experiments were repeated in triplicate. *p < 0.05, **p < 0.01, ***p < 0.001. ELISA, enzyme-linked immunosorbent assay; SAE, sepsis-associated encephalopathy; CLP, cecal ligation and puncture.