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. 2022 Jun 17;14(6):1296. doi: 10.3390/pharmaceutics14061296

Figure 2.

Figure 2

Prevention of PIPN signs with the curcumin and Meriva diets. (A) Mice were treated with cur-diet or Meriva-diet for 4 weeks (before, during, and after paclitaxel). (B) Motivation and locomotion were evaluated by the wheel-running test at D7. (C) Mechanical (von Frey test) and (D) cold (acetone test) hypersensitivity were tested at BL, D7, D14, and D21. (E) Sensory-nerve-conduction velocity and (F) sensory-nerve-compound-action-potential amplitude were measured at D22. Values are expressed as mean ± SEM. n = 12/group. Results were compared using two-way ANOVA (C,D), one-way ANOVA (B,E,F), and post-hoc Tukey’s test (*: p < 0.05, **: p < 0.01 and ***: p < 0.001 vs. reg-diet/Veh; (#: p < 0.05, ##: p < 0.01 and ###: p < 0.001 vs. reg-diet/PAC). BL = baseline; D = day; Cur = curcumin; Reg = regular; PAC = paclitaxel; Veh = vehicle.