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. 2022 Jun 17;14(6):1296. doi: 10.3390/pharmaceutics14061296

Figure 4.

Figure 4

Ur-diet mitigates the reduction in intraepidermal-nerve-fiber (IENF) density at 22 days post-paclitaxel injection. (A) Quantification of IENF density in hind-paw skin at day 22 post-treatment. (B) Immunostained sections of control (VEH), paclitaxel-treated group (PAC), the paclitaxel + curcumin 1.5%-treated group (PAC + Cur), and the paclitaxel + Meriva 1.5% -treated group (PAC + Meriva), with the hind-paw skin showing the IENFs. Values are expressed as mean ± SEM. n = 8/group. Results were compared using two-way ANOVA with post-hoc Tukey’s test and t-test (*: p < 0.05 vs. vehicle; #: p < 0.05 vs. Reg-diet/PAC). Reg = regular; Veh = vehicle; PAC = paclitaxel; Cur = curcumin. Bar scales: 20 μm.