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. 2022 Jun 17;14(6):1296. doi: 10.3390/pharmaceutics14061296

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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α-7 nicotinic acetylcholine receptor (α7 nAChR) mRNA expression in dorsal-root ganglia (DRG) and spinal cord: α7 nAChR mRNA expression was measured at day 22 after paclitaxel injection in DRG (A) and spinal cord (B). Values are expressed as mean ± SEM. n = 8/group. Results were compared using one-way ANOVA and post-hoc Tukey’s test (***: p < 0.001). (C) Mechanical hypersensitivity was tested at D7 and D14 after the first injection of paclitaxel with the von Frey test for Meriva-diet and MLA, an α7 nAChR antagonist. Values are expressed as mean ± SEM. n = 8/group. Results were compared using one-way ANOVA and post-hoc Tukey’s test (***: p < 0.001 vs. vehicle; ##: p < 0.05 vs. paclitaxel) Reg = regular; Veh = vehicle; PAC = paclitaxel; Cur = curcumin; D = day; MLA = methyllycaconitine citrate.