Figure 7.

Prevention of PIPN signs by Meriva diets depending on α7 nAChRs: WT and α7 nAChR KO mice were treated with Meriva-diet for 2 weeks (before, during and after paclitaxel). (A) Mechanical (von Frey test) and (B) cold (acetone test) hypersensitivity were tested at BL, D7, and D14. (C) Motivation and locomotion were evaluated by the wheel-running test at D7. (D) Sensory-nerve-compound-action-potential amplitude was measured at D21. Values are expressed as mean ± SEM. n = 8/group. Results were compared using two-way ANOVA (A,B) and one-way ANOVA (C,D) and post-hoc Tukey’s test (*: p < 0.05 and ***: p < 0.001 vs. WT reg-diet/Veh or KO reg-diet/Veh; (#: p < 0.05, ##: p < 0.01 and ###: p < 0.001 vs. WT reg-diet/PAC or KO reg-diet/PAC). WT = wild type; KO = knock out; Veh = vehicle; Reg = regular; PAC = paclitaxel; BL = baseline; D = day.