Skip to main content
. 2022 Jun 14;27(12):3816. doi: 10.3390/molecules27123816

Table 5.

miRs downregulated by polyphenols, cell types examined, and effects of miR downregulation.

miR CGA CUR EGCG GEN QUE RES Effects of miRs Downregulated by Polyphenols on Molecules in the ROS-Mediated Pathway:
↑, Upregulation;
↓, Downregulation
miR-20a Huh7
(Hepatoma)
H446
(lung carcinoma)
(Huang, et al.) [152]		 RKO
(colon cancer)
(Gandhy, et al.) [27]		 HUVEC (umbilical vascular endothelial cell cocultured with A549)
(Mirzaaghaei, et al.) [153]		 DU145
22RV1
(prostate cancer)
(Dhar, et al.) [154]
(CCL4-induced liver fibrotic cells)
(Zhu, et al.) [155]
DU145
(prostate cancer)
(Dhar, et al.) [156]		 ↑ p21 [152]
↑ PTEN [154]
↑ PTEN/PI3K/AKT [155]
miR-21 LX2
(hepatic stellate)
(Wang, et al.) [157]		 HCT116
RKO
(colorectal cancer)
(Mudduluru, et al.) [158]
AsPC-1
MiaPaCa-2
(pancreatic cancer)
CDF (analog)
(Bao, et al.) [147]
TE-7
(esophageal cancer)
(Subramaniam, et al.) [128]
PC-3
LNCaP
(prostate cancer)
Hypoxia
CDF (analog)
(Bao, et al.) [23]
A549
(lung cancer)
(Zhang, et al.) [159]
K562
LAMA84
(chronic myelogenous leukemia)
(Taverna, et al.) [160]
DU145
C4-2
(prostate cancer)
(Yallapu, et al.) [161]		 MCF-7
(breast cancer)
Polyphenon-60
(Fix, et al.) [162]
22Rv1 xenograft
(prostate tumor)
(Siddiqui, et al.) [163]		 A-498 xenograft
(renal cancer)
(Zaman, et al.) [164]		 SW480
(colon cancer)
(Tili, et al.) [165]
PC-3M-MM2
(prostate cancer)
(Sheth, et al.) [166]
PANC-1
CFPAC-1
MiaPaCa-2
(pancreatic cancer)
(Liu, et al.) [167]
U251
(glioblastoma)
(Li, et al.) [32]
T24
5637
(bladder cancer)
(Zhou, et al.) [29]		 ↓VEGF [23]
↓IL-6 [23]
↑PTEN [159,160]
↑p21 [164]
↓Bcl-2 [29,167]
↓NF-κB [32]
↓Akt [29]
miR-25 BxPC-3
(pancreatic cancer)
(Sun, et al.) [120]		 MCF-7
(breast cancer)
Polyphenon-60
(Fix, et al.) [162]
MM1.s
(multiple myeloma)
(Gordon, et al.) [140]
MCF-7
(breast cancer)
(Zan, et al.) [168]		 SW480
(colon cancer)
(Tili, et al.) [165]		 ↑ p53 [140]
↑Caspase-3 [168]
miR-27a HCT116p53±
SW480
(Toden, et al.) [127]
SW480
(colon cancer)
(Noratto, et al.) [169]
RKO
(colon cancer)
(Gandhy, et al.) [27]		 MCF-7
(breast cancer)
Polyphenon-60
(Fix, et al.) [162]		 PANC-1
BxPC-3
(pancreatic cancer)
(Cheng, et al.) [170]
SKOV3
(ovarian cancer)
(Xu, et al.) [171]
C918
(uveal melanoma)
(Sun, et al.) [172]
Upregulated *
A549
(lung cancer)
(Yang, et al.) [173]		 ↓VEGF via Sp1 [169]
↓VEGF via Sp1 [27]
↓EGFR [27]
↓Survivin [27]
↓Bcl-2 [27]
↓NF-κB [27]
↑FOXO1 [170]
miR-93 Huh7
(Hepatoma)
H446
(Lung carcinoma)
(Huang, et al.) [152]		 SK-N-BE2
IMR-32
(malignant neuroblastoma)
(Chakrabarti, et al.) [129]
SH-SY5Y
SK-N-DZ
(malignant neuroblastoma)
(Chakrabarti, et al.) [130]		 MCF-10A
(breast cancer)
(Singh, et al.) [174]		 ↑ p21 [152]
↑Caspase-3 [129,130]
miR-106b Huh7
(Hepatoma)
H446
(Lung carcinoma)
(Huang, et al.) [152]		 SK-N-BE2
IMR-32
(malignant neuroblastoma)
(Chakrabarti, et al.) [129]
SH-SY5Y
SK-N-DZ
(malignant neuroblastoma)
(Chakrabarti, et al.) [130]		 LNCaP
DU145
(prostate cancer)
(Dhar, et al.) [156]
DU145
22RV1
(prostate cancer) (Dhar, et al.) [154]		 ↑ p21 [152]
↑ PTEN [154,156]
miR-155 RAW264.7
(mouse macrophage)
(Zeng, et al.) [21]		 RAW264.7
(mouse macrophage)
THP1
(acute monocyte leukemia)
(Ma, et al.) [30]		 MDA-MB-435
Hs578t
(breast cancer)
(Parra, et al.) [175]
(Basu, et al.) [196]		 RAW264.7
(mouse macrophage)
(Boesch-Saadatmandi, et al.) [176]		 THP-1
(monocyte)
(Tili, et al.) [177]		 ↓ NF-κB [21]
↑ PTEN [175]
miR-221 MiaPaCa-2
(pancreatic cancer)
CDF (analog)
(Sarkar, et al.) [178]
HepG2 tumor
(HCC orthotopic mouse model)
(Zhang, et al.) [24]
SW1736
(Anaplastic thyroid carcinoma)
(Allegri, et al.) [179]		 SW1736
(Anaplastic thyroid carcinoma)
(Allegri, et al.) [179]
Upregulated *
HepG2 (liver cancer)
(Tsang, et al.) [115]		 PC-3
(prostate cancer)
(Chen, et al.) [180]
SW1736
(Anaplastic thyroid carcinoma)
(Allegri, et al.) [179]		 WI-38
(lung fibroblast)
(Wang, et al.) [181]		 ↑ PTEN [178]
↓VEGF [24]

* The items shown in italics are different findings from other reported results (see Text).