Table 4.
Comparison of brain structures between Remote-SA, Lifetime-SI only, and non-suicidal depressed analyzed in Study 1 with ComBat harmonization.
| Region of Interest | Remote-SA (n = 21) Mean ± SD | Lifetime-SI only (n = 72) Mean ± SD | Depressed (n = 94) Mean ± SD | p-value adjusted |
|---|---|---|---|---|
| Cortical thickness | ||||
| Caudal ACC | 4.96 ± 0.45 | 5.22 ± 0.39 | 5.10 ± 0.37 | p=.163 |
| IFG | 15.39 ± 0.73 | 15.84 ± 0.90 | 15.67 ± 0.88 | p=.499 |
| Inferior temporal | 5.53 ± 0.29 | 5.67 ± 0.38 | 5.63 ± 0.26 | p=.465 |
| Insula | 5.96 ± 0.29 | 6.05 ± 0.36 | 6.02 ± 0.32 | p=.721 |
| Lateral OFC | 5.22 ± 0.32 | 5.39 ± 0.33 | 5.34 ± 0.29 | p=.575 |
| Medial OFC | 4.74 ± 0.37 | 4.90 ± 0.35 | 4.87 ± 0.29 | p=.385 |
| Middle temporal | 5.68 ± 0.24 | 5.81 ± 0.35 | 5.82 ± 0.32 | p=.118 |
| Superior frontal | 5.32 ± 0.30 | 5.51 ± 0.32 | 5.46 ± 0.36 | p=.180 |
| Superior parietal | 4.16 ± 0.23 | 4.34 ± 0.25 | 4.28 ± 0.26 | p=.098 |
| Superior temporal | 5.45 ± 0.28 | 5.68 ± 0.35 | 5.61 ± 0.34 | p=.161 |
| Surface area | ||||
| Caudal ACC | 1361.02 ± 232.94 | 1385.68 ± 267.82 | 1390.49 ± 228.09 | p=.805 |
| IFG | 7043.28 ± 608.77 | 7049.91 ± 858.15 | 7122.42 ± 850.38 | p=.461 |
| Inferior temporal | 6042.10 ± 701.65 | 6200.07 ± 823.18 | 6114.38 ± 852.41 | p=.691 |
| Insula | 4296.49 ± 431.42 | 4300.67 ± 467.82 | 4388.45 ± 481.65 | p=.344 |
| Lateral OFC | 4969.45 ± 406.97 | 4967.83 ± 552.57 | 5050.15 ± 640.72 | p=.312 |
| Medial OFC | 3590.52 ± 438.23 | 3481.19 ± 420.08 | 3567.48 ± 439.26 | p=.395 |
| Middle temporal | 6270.01 ± 716.28 | 6160.69 ± 783.14 | 6266.21 ± 788.10 | p=.416 |
| Superior frontal | 13,937.37 ± 1238.26 | 13,640.99 ± 1526.56 | 13,857.16 ± 1549.99 | p=.399 |
| Superior parietal | 10,745.24 ± 1127.78 | 10,389.64 ± 1220.73 | 10,504.54 ± 1141.43 | p=.356 |
| Superior temporal | 7276.52 ± 761.19 | 7122.71 ± 782.95 | 7173.04 ± 786.20 | p=.794 |
| Subcortical volume | ||||
| Caudate | 6929.61 ± 679.74 | 7253.30 ± 1076.68 | 7069.78 ± 1020.22 | p=.281 |
| Hippocampus | 8709.81 ± 616.48 | 8558.47 ± 883.98 | 8624.69 ± 796.66 | p=.741 |
| Putamen | 10,194.39 ± 1542.83 | 10,897.33 ± 1420.78 | 10,545.93 ± 1434.16 | p=.412 |
| Thalamus | 15,604.80 ± 1298.98 | 16,087.51 ± 1759.06 | 16,060.78 ± 1958.85 | p=.414 |
| Nucleus Accumbens | 1103.83 ± 189.46 | 1114.61 ± 192.53 | 1085.16 ± 215.35 | p=.921 |
ACC: anterior cingulate cortex; IFG: inferior frontal gyrus; OFC = orbitofrontal cortex.
Cortical thickness is expressed in millimeters; Surface area is expressed in millimeters2; Volume is expressed in millimeters3.