Table 6.
Comparison of brain structures between Recent-SA, Remote-SA, Lifetime-SI only, and non-suicidal depressed analyzed in Study 3 (EMBARC + Little Rock combined).
| Region of Interest | Recent-SA (n = 11) Mean ± SD | Remote-SA (n = 32) Mean ± SD | Lifetime-SI (n = 84) Mean ± SD | Depressed (n = 96) Mean ± SD | p-value adjusted |
|---|---|---|---|---|---|
| Cortical Thickness | |||||
| Caudal ACC | 5.40 ± 0.23 | 5.10 ± 0.52 | 5.23 ± 0.44 | 5.11 ± 0.35 | p=.224 |
| IFG | 15.00 ± 0.51 | 15.22 ± 0.92 | 15.61 ± 1.04 | 15.62 ± 0.95 | p=.048 |
| Inferior temporal | 5.06 ± 0.25b | 5.39 ± 0.39 | 5.59 ± 0.45 | 5.61 ± 0.28b | p=.022 # |
| Insula | 6.00 ± 0.24 | 5.96 ± 0.36 | 6.03 ± 0.38 | 6.02± 0.33 | p=.822 |
| Lateral OFC | 5.02 ± 0.24 | 5.17 ± 0.35 | 5.32 ± 0.37 | 5.32 ± 0.35 | p=.374 |
| Medial OFC | 4.62 ± 0.23 | 4.75 ± 0.43 | 4.86 ± 0.35 | 4.86 ± 0.34 | p=.749 |
| Middle temporal | 5.38 ± 0.28b | 5.61 ± 0.31 | 5.72 ± 0.4d | 5.80 ± 0.33b,d | p=.002 * |
| Superior frontal | 5.42 ± 0.24 | 5.30 ± 0.34 | 5.46 ± 0.34 | 5.45 ± 0.36 | p=.218 |
| Superior parietal | 4.32± 0.19 | 4.22 ± 0.29 | 4.30 ± 0.29 | 4.28 ± 0.26 | p=.617 |
| Superior temporal | 5.39 ± 0.25 | 5.44 ± 0.33 | 5.62 ± 0.38 | 5.60 ± 0.35 | p=.247 |
| Surface area | |||||
| Caudal ACC | 1359.36 ± 209.15 | 1416.56 ± 293.22 | 1391.63 ± 286.14 | 1390.08 ± 235.99 | p=.914 |
| IFG | 6266.36 ± 671.27 | 7027.56 ± 862.52 | 7059.37 ± 885.63 | 7048.59 ± 862.42 | p=.088 |
| Inferior temporal | 5844.55 ± 638.42 | 6135.34 ± 944.01 | 6184.64 ± 830.98 | 6124.66 ± 897.57 | p=.494 |
| Insula | 3682.82 ± 289.84a,b | 4192.50 ± 497.88 | 4295.49 ± 512.30a | 4373.02 ± 480.52b | p=.003 * |
| Lateral OFC | 4626.91 ± 469.19 | 4927.97 ± 611.31 | 4975.86 ± 579.66 | 5047.33 ± 636.58 | p=.246 |
| Medial OFC | 3252.18 ± 404.17 | 3543.59 ± 508.88 | 3507.33 ± 436.77 | 3563.06 ± 432.95 | p=.277 |
| Middle temporal | 5773.45 ± 575.01 | 6246.44 ± 945.15 | 6180.11 ± 798.68 | 6263.04 ± 783.26 | p=.314 |
| Superior frontal | 12,837.00 ± 1180.85 | 13,752.19 ± 1555.43 | 13,742.50 ± 1608.75 | 13,836.16 ± 1536.50 | p=.541 |
| Superior parietal | 9522.36 ± 1178.00 | 10,661.29 ± 1182.44 | 10,433.12 ± 1238.30 | 10,523.22 ± 1137.02 | p=.092 |
| Superior temporal | 6544.45 ± 350.20 | 7174.16 ± 900.24 | 7150.95 ± 814.10 | 7168.88 ± 752.90 | p=.172 |
| Subcortical volume | |||||
| Caudate | 7257.12 ± 599.28 | 7007.24 ± 966.71 | 7304.42 ± 1136.52 | 7073.77 ± 1067.36 | p=.499 |
| Hippocampus | 7604.11 ± 578.20 | 8351.74 ± 929.84 | 8493.43 ± 940.24 | 8600.43 ± 817.52 | p=.192 |
| Putamen | 11,098.31 ± 802.74 | 10,778.74 ± 1890.76 | 11,045.56 ± 1622.42 | 10,556.02 ± 1601.43 | p=.898 |
| Thalamus | 12,944.33 ± 864.88a,b | 14,805.66 ± 1906.41 | 15,740.29 ± 2144.77a | 15,951.06 ± 2060.73b | p=.003 * |
| Nucleus Accumbens | 1411.95 ± 206.48a,b | 1205.84 ± 302.87 | 1163.60 ± 261.04a | 1088.16 ± 247.88b | p=.014 * |
ACC: anterior cingulate cortex; IFG: inferior frontal gyrus; OFC = orbitofrontal cortex.
Cortical thickness is expressed in millimeters; Surface area is expressed in millimeters2. Volume is expressed in millimeters3.
*
Statistically significant.
#
Trending towards significance.
a
Statistically significant between Recent-SA and Lifetime-SI.
b
Statistically significant between Recent-SA and Depressed.
c
Statistically significant between Remote-SA and Depressed.
d
Statistically significant between Lifetime-SI and Depressed.
p-FDR ≤ 0.10.