Table 2.
Neural Activity Within Independent Components Identified Through Independent Component Analysis During the Resting State in Suicide Attempters, Suicidal Ideators, Depressed Non-Suicidal Controls, and Healthy Controlsa
| Region (Brodmann Area) | Cluster Size (no. of Voxels) | Peak Voxel t-Score | Peak Voxel MNI Coordinates | ||
|---|---|---|---|---|---|
| x | y | z | |||
| Limbic network | |||||
| Component 13 | |||||
| Putamen (l 34) | 1,581 | 20.81 | −25.5 | 7.5 | 5.5 |
| Component 14 | |||||
| Parahippocampal gyrus (r 38) | 1,414 | 22.15 | 25.5 | −1.5 | −18.5 |
| Component 18 | |||||
| Thalamus (r 27) | 524 | 22.18 | −4.5 | −31.5 | −3.5 |
| Central executive network | |||||
| Component 26 | |||||
| Middle frontal gyrus (r 8) | 1,318 | 19.01 | 25.5 | 25.5 | 53.5 |
| Inferior parietal lobule (r 40) | 456 | 20.10 | 49.5 | −52.5 | 41.5 |
| Component 29 | |||||
| Middle frontal gyrus (l 10) | 1,112 | 18.83 | −43.5 | 43.5 | 5.5 |
| Inferior parietal lobule (l 40) | 456 | 17.12 | −43.5 | −46.5 | 41.5 |
| Component 30 | |||||
| Inferior frontal gyrus (r 9) | 806 | 19.96 | 52.5 | 25.5 | 11.5 |
| Inferior frontal gyrus (r 46) | 379 | 16.22 | −43.5 | 34.5 | 5.5 |
| Salience network | |||||
| Component 22 | |||||
| Superior temporal gyrus (r 13) | 564 | 21.40 | 46.5 | 16.5 | −6.5 |
| Superior temporal gyrus (l 13) | 513 | 19.51 | −49.5 | 13.5 | −6.5 |
| Component 24 | |||||
| Medial frontal gyrus (r 6) | 1,465 | 28.37 | 4.5 | 19.5 | 38.5 |
| Insula (l 13) | 364 | 21.28 | −40.5 | 16.5 | 8.5 |
| Insula (r 13) | 342 | 23.88 | 46.5 | 13.5 | −0.5 |
| Component 28 | |||||
| Dorsal insula (r 13) | 1,428 | 23.66 | 40.5 | −10.5 | 11.5 |
| Dorsal insula (l 13) | 1,214 | 21.10 | −61.5 | −13.5 | 11.5 |
| Default mode network | |||||
| Component 4 | |||||
| Cuneus (18) | 2,210 | 28.33 | −1.5 | −67.5 | 8.5 |
| Component 6 | |||||
| Dorsal precuneus (7) | 996 | 22.51 | −1.5 | −62.5 | 44.5 |
| Component 11 | |||||
| Ventral precuneus (31) | 1,146 | 26.41 | 1.5 | −37.5 | 26.5 |
| Component 16 | |||||
| Medial frontal gyrus (9) | 1,794 | 30.57 | −4.5 | 43.5 | 2.5 |
| Cingulate (31) | 252 | 19.37 | −1.5 | −22.5 | 41.5 |
| Component 17 | |||||
| Retrosplenial cortex (l 31) | 846 | 28.10 | −7.5 | −58.5 | 14.5 |
| Component 20 | |||||
| Superior frontal gyrus (l 8) | 889 | 20.10 | −1.5 | 52.5 | 35.5 |
| Precuneus (l 31) | 337 | 25.68 | −1.5 | −58.5 | 26.5 |
| Superior temporal gyrus (l 39) | 243 | 15.13 | −46.5 | −55.5 | 23.5 |
| Sensorimotor network | |||||
| Component 21 | |||||
| Post central gyrus (l 6) | 2,581 | 26.19 | 1.5 | −13.5 | 50.5 |
| Component 23 | |||||
| Inferior parietal lobule (r 40) | 781 | 26.19 | 1.5 | −13.5 | 50.5 |
| Inferior parietal lobule (l 40) | 520 | 21.92 | 37.5 | −43.5 | 41.5 |
| Component 27 | |||||
| Precentral gyrus (l 4) | 233 | 15.70 | −52.5 | −10.5 | 41.5 |
| Precentral gyrus (r 4) | 213 | 15.00 | 52.5 | −10.5 | 35.5 |
| Inferior parietal lobule (r 40) | 150 | −15.14 | 52.5 | −37.5 | 29.5 |
| Occipital network | |||||
| Component 5 | |||||
| Lingual gyrus (l 18) | 1,287 | 19.47 | −4.5 | −76.5 | −9.5 |
| Component 15 | |||||
| Middle occipital gyrus (r 19) | 1,220 | 18.35 | 25.5 | −46.5 | −9.5 |
| Middle occipital gyrus (l 19) | 773 | 18.47 | −28.5 | −52.5 | −12.5 |
| Cerebellum network | |||||
| Component 9 | |||||
| Culmen (l 19) | 1,773 | 19.99 | −28.5 | −43.5 | −24.5 |
a
Independent component analyses used data from all voxels. These clusters were arbitrarily thresholded at cluster > 20 and P < .005 to aid visualization of the networks.
Abbreviation: MNI = Montreal Neurological Institute.