Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Schematic diagram of the antidepressant-like Gypenoside XVII in CUMS-induced mice. Chronic stress activates microglia and enhances C3 release. C3 targets neuron and recruit microglia to eliminate targeted synapses. Meanwhile, C3 binds with C3aR to activate STAT3. Subsequently, STAT3 induces the activation of the pro-inflammatory cytokine to aggravate the inflammatory response.
