Table 3.
List of antigens for which antibody levels are significantly different between ME/CFS and healthy controls by sex. Values are given as log2 MFI averages ± standard deviations. Blue indicates lower antibody levels in cases than in controls. Red indicates lower levels in controls than in cases. n = number of antigens with significant differences (p < 0.05) in antibody levels between case and control. p = p-value, q = q-value.
| Male (n = 42: Top 9 Ranked by p-Value + Rotavirus-SA11) | Female (n = 4) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Pathogen | ME/CFS | Control | p | q | Pathogen | ME/CFS | Control | p | q |
| B.burgdorferi-lysate | 1.0 ± 0.6 | 2.0 ± 0.7 | 0.000 | 0.01 | Streptococcus dysgalactiae-lysate | 2.6 ± 0.7 | 3.2 ± 0.6 | 0.003 | 0.39 |
| EBV-EBNA1 | 3.0 ± 0.9 | 4.4 ± 1.2 | 0.002 | 0.12 | Streptococcus pyogenes-lysate2 | 5.2 ± 1.7 | 6.2 ± 1.9 | 0.010 | 0.47 |
| RhinoA15-lysate | 2.3 ± 0.5 | 2.9 ± 0.5 | 0.005 | 0.12 | EBV-gp125 | 7.1 ± 0.8 | 6.7 ± 0.9 | 0.012 | 0.47 |
| Astrovirus-lysate | 1.6 ± 0.3 | 2.2 ± 0.6 | 0.005 | 0.12 | Rotavirus-SA11 | 2.9 ± 0.6 | 2.6 ± 0.5 | 0.033 | 0.98 |
| HEV-Orf2 | 3.2 ± 0.8 | 4.1 ± 0.8 | 0.007 | 0.12 | |||||
| RhinoB14-lysate | 2.1 ± 0.4 | 2.5 ± 0.3 | 0.010 | 0.12 | |||||
| SARS2-lysate | 1.3 ± 0.4 | 1.9 ± 0.5 | 0.010 | 0.12 | |||||
| CoxB2-lysate | 0.9 ± 0.2 | 1.4 ± 0.5 | 0.012 | 0.12 | |||||
| C. trachomatis-lysate | 0.8 ± 0.3 | 1.3 ± 0.6 | 0.014 | 0.12 | |||||
| Rotavirus-SA11 | 2.4 ± 0.5 | 2.9 ± 0.7 | 0.025 | 0.12 | |||||