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. 2022 May 26;10(6):1097. doi: 10.3390/microorganisms10061097

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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(A) Schematic genetic diagram of pEGY22_CTX-M-15 convergent plasmid harbored by the K. pneumoniae K22 strain showing a detailed representation of multidrug-resistant and virulence regions. The arrows indicate ORFs with magenta, light green, dark green, aqua, blue, yellow, pink, and red representing functional ORFs, virulence factor genes, heavy metal resistance genes, transposons, insertion sequence elements, plasmid replicon type, CRISPR array, and antimicrobial genes, respectively; (B) BRIG visualization comparing IncHI1B/IncFIB-bla_CTX-M-15-positive K. pneumoniae plasmids. Circles from inside to outside show the coding sequencing region of pNDM-MAR (JN420336.1), p17-15-vir-like (MN956836.1), phvKpST395_NDM-1_2512 (MW911670.1), pKpvST383 (CP034201.2), and pEGY22_CTX-M-15 (ON261191). GC skew (dark green and magenta) and GC content (black) are represented in the inner circles.

(A) Schematic genetic diagram of pEGY22_CTX-M-15 convergent plasmid harbored by the K. pneumoniae K22 strain showing a detailed representation of multidrug-resistant and virulence regions. The arrows indicate ORFs with magenta, light green, dark green, aqua, blue, yellow, pink, and red representing functional ORFs, virulence factor genes, heavy metal resistance genes, transposons, insertion sequence elements, plasmid replicon type, CRISPR array, and antimicrobial genes, respectively; (B) BRIG visualization comparing IncHI1B/IncFIB-bla_CTX-M-15-positive K. pneumoniae plasmids. Circles from inside to outside show the coding sequencing region of pNDM-MAR (JN420336.1), p17-15-vir-like (MN956836.1), phvKpST395_NDM-1_2512 (MW911670.1), pKpvST383 (CP034201.2), and pEGY22_CTX-M-15 (ON261191). GC skew (dark green and magenta) and GC content (black) are represented in the inner circles.