TABLE 5.
Association of plasma NfL with neuropsychological outcomes covarying for age, education, sex, and primary language separated by diagnostic status
| B | Std. Error | Standardized B | P ‐value | |
|---|---|---|---|---|
| MMSE | ||||
| NHW | ||||
| NC (n = 673) | ‐0.010 | 0.004 | ‐0.096 | .023* |
| MCI (n = 91) | ‐0.004 | 0.013 | ‐0.037 | .771 |
| Dementia (n = 49) | ‐0.046 | 0.042 | ‐0.166 | .279 |
| MA | ||||
| NC (n = 676) | 0.003 | 0.008 | 0.013 | .702 |
| MCI (n = 152) | 0.003 | 0.018 | 0.012 | .851 |
| Dementia (n = 62) | ‐0.100 | 0.039 | ‐0.254 | .013* |
| Digit Symbol | ||||
| NHW | ||||
| NC | ‐0.113 | 0.040 | ‐0.110 | .004* |
| MCI | ‐0.220 | 0.076 | ‐0.338 | .005* |
| Dementia | 0.060 | 0.098 | 0.087 | .543 |
| MA | ||||
| NC | ‐0.062 | 0.028 | ‐0.054 | .029* |
| MCI | ‐0.134 | 0.060 | ‐0.134 | .026* |
| Dementia | ‐0.206 | 0.075 | ‐0.261 | .009* |
| WMS Digit Span | ||||
| NHW | ||||
| NC | ‐0.023 | 0.015 | ‐0.064 | .140 |
| MCI | ‐0.009 | 0.027 | ‐0.042 | .738 |
| Dementia | ‐0.043 | 0.027 | ‐0.263 | .120 |
| MA | ||||
| NC | 0.002 | 0.011 | 0.007 | .838 |
| MCI | ‐0.027 | 0.019 | ‐0.106 | .159 |
| Dementia | ‐0.051 | 0.021 | ‐0.292 | .021* |
| TMTA | ||||
| NHW | ||||
| NC | 0.105 | 0.043 | 0.098 | .015* |
| MCI | 0.357 | 0.145 | 0.270 | .016* |
| Dementia | ‐0.028 | 0.506 | ‐0.009 | .957 |
| MA | ||||
| NC | 0.126 | 0.067 | 0.064 | .061 |
| MCI | 0.128 | 0.211 | 0.041 | .546 |
| Dementia | 0.687 | 0.354 | 0.216 | .058 |
| TMTB | ||||
| NHW | ||||
| NC | 0.154 | 0.147 | 0.041 | .294 |
| MCI | 0.620 | 0.594 | 0.116 | .300 |
| Dementia | 1.262 | 0.982 | 0.197 | .209 |
| MA | ||||
| NC | 0.399 | 0.231 | 0.055 | .086 |
| MCI | 0.423 | 0.498 | 0.057 | .396 |
| Dementia | 0.698 | 0.597 | 0.152 | .250 |
| FAS | ||||
| NHW | ||||
| NC | ‐0.091 | 0.045 | ‐0.084 | .042* |
| MCI | ‐0.103 | 0.097 | ‐0.140 | .289 |
| Dementia | ‐0.156 | 0.100 | ‐0.262 | .127 |
| MA | ||||
| NC | ‐0.056 | 0.034 | ‐0.059 | .095 |
| MCI | ‐0.039 | 0.058 | ‐0.052 | .499 |
| Dementia | ‐0.217 | 0.064 | ‐0.374 | .001* |
| Animals | ||||
| NHW | ||||
| NC | ‐0.017 | 0.019 | ‐0.037 | .382 |
| MCI | ‐0.065 | 0.036 | ‐0.205 | .079 |
| Dementia | ‐0.086 | 0.053 | ‐0.245 | .113 |
| MA | ||||
| NC | ‐0.006 | 0.015 | ‐0.016 | .659 |
| MCI | ‐0.013 | 0.028 | ‐0.039 | .630 |
| Dementia | ‐0.075 | 0.037 | ‐0.249 | .050 |
| LM1 | ||||
| NHW | ||||
| NC | ‐0.025 | 0.039 | ‐0.026 | .528 |
| MCI | 0.187 | 0.080 | 0.276 | .021* |
| Dementia | ‐0.031 | 0.102 | ‐0.049 | .762 |
| MA | ||||
| NC | ‐0.026 | 0.032 | ‐0.031 | .409 |
| MCI | 0.067 | 0.063 | 0.084 | .289 |
| Dementia | ‐0.076 | 0.091 | ‐0.113 | .403 |
| LM2 | ||||
| NHW | ||||
| NC | ‐0.037 | 0.030 | ‐0.051 | .220 |
| MCI | 0.153 | 0.062 | 0.293 | .016* |
| Dementia | ‐0.038 | 0.063 | ‐0.092 | .552 |
| MA | ||||
| NC | ‐0.006 | 0.025 | ‐0.009 | .803 |
| MCI | 0.067 | 0.051 | 0.108 | .193 |
| Dementia | ‐0.052 | 0.055 | ‐0.123 | .34 |
| SEVLT 1‐5 total | ||||
| NHW | ||||
| NC | ‐0.055 | 0.030 | ‐0.069 | .070 |
| MCI | 0.021 | 0.048 | 0.051 | .660 |
| Dementia | ‐0.079 | 0.065 | ‐0.182 | .231 |
| MA | ||||
| NC | ‐0.021 | 0.024 | ‐0.031 | .382 |
| MCI | ‐0.011 | 0.041 | ‐0.022 | .786 |
| Dementia | ‐0.150 | 0.072 | ‐0.284 | .041* |
| SEVLT delayed recall | ||||
| NHW | ||||
| NC | ‐0.022 | 0.011 | ‐0.079 | .049* |
| MCI | 0.004 | 0.023 | 0.022 | .855 |
| Dementia | 0.004 | 0.020 | 0.026 | .857 |
| MA | ||||
| NC | ‐0.011 | 0.010 | ‐0.039 | .277 |
| MCI | 0.047 | 0.020 | 0.194 | .019* |
| Dementia | ‐0.036 | 0.022 | ‐0.229 | .098 |