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. 2022 Jun 10;14(6):1233. doi: 10.3390/pharmaceutics14061233

Figure 1.

Figure 1

AFM, size, zeta potential, loading efficiency, and drug release of M13/nLNP. (A) Representative AFM image; (B) size distribution showed that the average size of M13/nLNP was 182.8 ± 10 nanometers (n = 3) and with a Polydispersity Index (PDI) of 0.196; (C) zeta potential of M13/nLNP was −18.3 ± 0.5 mV in PBS (n = 3); (D) zeta potential of M13/nLNP was −23.3 ± 0.9 mV in deionized water (n = 3); (E) representative high-performance liquid chromatography (HPLC) profile quantifying M13 in total M13/nLNP suspension (red), free M13 in filtered-through solution (blue), and the loading efficacy of M13 in nLNP ((n = 3); (F) M13/nLNP drug release profile in the ex vivo culture medium (pH~7.4); (G) modeling of the M13 release from the nLNP matrix (Higuchi model, R2 = 0.9424); (H) modeling of the M13 release from nLNP matrix, from left to right: zero-order kinetics (R2 = 0.8227), first-order kinetics (R2 = 0.9166), Korsmeyer–Peppas (R2 = 0.9061), and Hixson–Crowell model (R2 = 0.896).