Figure 1.

Invasive candidiasis involves rapid dissemination of Candida yeast cells in the bloodstream (candidemia BSI) and/or tissue penetration by invasive hypha (deep-seated candidiasis). Hematogenous seeding of Candida yeast from blood-borne candidemia is often a key source of tissue candidiasis and vice versa [9]. Although hyphal extension is a well-described mechanism of C. albicans tissue invasion, its role is less clear for other clinically important Candida species such as C. glabrata where other mechanisms of invasion may be involved.