Table 1.
Baseline characteristics and endpoints of the study population, overall and by APOE-ε4 carriership.
| Variable | All Population (n = 1490) |
APOE-ε4 Non-carrier (n = 1155) 1 |
APOE-ε4 Carrier (n = 335) 2 |
ε3/ε4 + ε4/ε4
(n = 311) |
|---|---|---|---|---|
| Women—No. (%) | 798 (53.6) | 620 (53.7) | 178 (53.1) | 167 (53.7) |
| Age—Mean (SD) | 73.0 (5.7) | 73.2 (5.8) | 72.4 (5.5) 3 | 72.5 (5.5) |
| Education—No. (%) | ||||
| No high school degree | 64 (4.3) | 49 (4.2) | 15 (4.5) | 15 (4.5) |
| High school degree | 341 (22.9) | 275 (23.8) | 66 (19.7) | 62 (20.0) |
| Some years of college | 366 (24.6) | 282 (24.4) | 84 (25.1) | 77 (24.8) |
| College degree | 505 (33.9) | 384 (33.2) | 121 (36.1) | 112 (36.0) |
| Unknown | 214 (14.4) | 165 (14.6) | 49 (14.6) | 45 (14.5) |
| Diabetes—No. (%) | 256 (17.2) | 202 (17.5) | 54 (16.1) | 53 (17.0) |
| Prevalent cardiovascular disease—No. (%) | 330 (22.1) | 252 (21.8) | 78 (23.3) | 74 (23.8) |
| RBC DHA, proportion of total fatty acids—Mean (SD) | 5.00 (1.37) | 5.00 (1.37) | 5.00 (1.39) | 5.04 (1.40) |
| Incident Alzheimer’s disease—No. (%) | 131 (8.8) | 77 (6.7) | 54 (16.1) 3 | 51 (16.4) 3 |
| Incident all-cause dementia—No. (%) | 168 (11.3) | 103 (8.9) | 65 (19.4) 3 | 61 (19.6) 3 |
1 Includes ε2/ε2 (n = 7), ε2/ε3 (n = 191), and ε3/ε3 (n = 957). 2 Includes ε2/ε4 (n = 24), ε3/ε4 (n = 286), and ε4/ε4 (n = 25). 3 p < 0.05 vs. non-carrier. DHA, docosahexaenoic acid; RBC, red blood cell.