Table 2.
Hazard ratios (HR) for red blood cell DHA on Alzheimer’s disease (AD) and all-cause dementia (n = 1490).
| Endpoint | HR (95% CI) for Quintiles of Red Blood Cell DHA | HR (95% CI) per SD 1 | |||||
|---|---|---|---|---|---|---|---|
| Q1 (<3.8%, Median = 3.4%) (n = 300) |
Q2 (3.8% to <4.5%, Median = 4.2%) (n = 298) |
Q3 (4.5% to <5.2%, Median = 4.8%) (n = 297) |
Q4 (5.2% to 6.1%, Median = 5.6%) (n = 297) |
Q5 (>6.1%, Median = 6.97%) (n = 295) |
p for Trend | ||
| AD | |||||||
| N. of cases | 29 | 30 | 24 | 29 | 19 | 131 | |
| Model 1 | 1.00 | 0.72 (0.43, 1.21) | 0.61 (0.34, 1.09) | 0.72 (0.41, 1.25) | 0.48 (0.26, 0.87) | 0.04 | 0.80 (0.66, 0.98) |
| Model 2 | 1.00 | 0.78 (0.45, 1.33) | 0.64 (0.35, 1.18) | 0.75 (0.42, 1.35) | 0.51 (0.27, 0.98) | 0.07 | 0.82 (0.67, 1.01) |
| Model 3 | 1.00 | 0.77 (0.45, 1.33) | 0.64 (0.35, 1.18) | 0.75 (0.42, 1.33) | 0.51 (0.27, 0.96) | 0.06 | 0.82 (0.66, 1.00) |
| Dementia | |||||||
| N. of cases | 35 | 38 | 29 | 40 | 26 | 168 | |
| Model 1 | 1.00 | 0.78 (0.49, 1.26) | 0.64 (0.38, 1.08) | 0.87 (0.54, 1.41) | 0.56 (0.33, 0.94) | 0.09 | 0.85 (0.72, 1.01) |
| Model 2 | 1.00 | 0.80 (0.49, 1.29) | 0.65 (0.38, 1.11) | 0.88 (0.54, 1.45) | 0.57 (0.33, 0.99) | 0.12 | 0.86 (0.73, 1.03) |
| Model 3 | 1.00 | 0.79 (0.49, 1.29) | 0.64 (0.37, 1.11) | 0.87 (0.53, 1.44) | 0.56 (0.32, 0.97) | 0.10 | 0.86 (0.72, 1.02) |
1 1 SD = 1.4% of total fatty acids. CI = confidence interval; Q = quintile; SD = standard deviation. Model 1, adjusted for age, sex, and APOE-ε4 carriership (non-carrier vs. carrier); model 2, further adjusted for education (no high-school degree vs. high school degree vs. some years of college vs. college degree vs. unknown) and baseline diabetes (yes vs. no); model 3, further adjusted for prevalent cardiovascular disease at baseline (yes vs. no).