Table 3.
Hazard ratios (HR) for red blood cell DHA on Alzheimer’s disease (AD) and all-cause dementia (n = 1453) ignoring 37 individuals with incident Alzheimer’s or all-cause dementia within five years of baseline.
| Endpoint | HR (95% CI) for Quintiles of Red Blood Cell DHA | HR (95% CI) per SD 1 | |||||
|---|---|---|---|---|---|---|---|
| Q1 (<3.8%, Median = 3.4%) (n = 284) |
Q2 (3.8% to <4.5%, Median = 4.2%) (n = 282) |
Q3 (4.5% to <5.2%, Median = 4.8%) (n = 284) |
Q4 (5.2% to 6.1%, Median = 5.6%) (n = 280) |
Q5 (>6.1%, Median = 6.97%) (n = 283) |
p for Trend | ||
| AD | |||||||
| N. of cases | 15 | 18 | 9 | 17 | 13 | 72 | |
| Model 1 | 1.00 | 0.82 (0.41, 1.66) | 0.41 (0.17, 0.99) | 0.81 (0.38, 1.73) | 0.61 (0.28, 1.32) | 0.29 | 0.84 (0.64, 1.11) |
| Model 2 | 1.00 | 0.82 (0.40, 1.69) | 0.40 (0.16, 0.95) | 0.82 (0.37, 1.82) | 0.57 (0.24. 1.34) | 0.29 | 0.84 (0.62, 1.12) |
| Model 3 | 1.00 | 0.80 (0.39, 1.65) | 0.38 (0.16, 0.92) | 0.77 (0.35, 1.73) | 0.53 (0.22, 1.26) | 0.23 | 0.81 (0.61, 1.09) |
| Dementia | |||||||
| N. of cases | 19 | 22 | 13 | 23 | 14 | 91 | |
| Model 1 | 1.00 | 0.81 (0.43, 1.53) | 0.49 (0.24, 1.03) | 0.91 (0.48, 1.76) | 0.53 (0.26, 1.09) | 0.18 | 0.83 (0.66, 1.05) |
| Model 2 | 1.00 | 0.77 (0.41, 1.46) | 0.47 (0.23, 0.98) | 0.89 (0.45, 1.76) | 0.49 (0.23, 1.04) | 0.17 | 0.82 (0.64, 1.05) |
| Model 3 | 1.00 | 0.75 (0.39, 1.42) | 0.45 (0.21, 0.95) | 0.84 (0.43, 1.67) | 0.45 (0.21, 0.97) | 0.11 | 0.81 (0.63, 1.02) |
1 1 SD = 1.4% of total fatty acids. CI = confidence interval; Q = quintile; SD = standard deviation. See Table 2 for detailed information on statistical models.