Table 4.
Hazard ratios (HR) for red blood cell EPA on Alzheimer’s disease (AD) and all-cause dementia (n = 1490).
| Endpoint | HR (95% CI) for Quintiles of Red Blood Cell EPA | HR (95% CI) per SD 1 | |||||
|---|---|---|---|---|---|---|---|
| Q1 (<0.44%, Median = 0.37%) (n = 303) |
Q2 (0.44% to <0.55%, Median = 0.49%) (n = 294) |
Q3 (0.55% to <0.70%, Median = 0.61%) (n = 299) |
Q4 (0.70% to 0.95%, Median = 0.78%) (n = 297) |
Q5 (>0.95%, Median = 1.21%) (n = 297) |
p for Trend | ||
| AD | |||||||
| N. of cases | 39 | 31 | 42 | 27 | 29 | 168 | |
| Model 1 | 1.00 | 0.68 (0.42, 1.10) | 0.97 (0.62, 1.51) | 0.53 (0.32, 0.91) | 0.74 (0.46, 1.20) | 0.10 | 0.97 (0.81, 1.16) |
| Model 2 | 1.00 | 0.69 (0.42, 1.12) | 0.99 (0.63, 1.55) | 0.57 (0.33, 0.98) | 0.76 (0.46, 1.25) | 0.19 | 0.98 (0.81, 1.16) |
| Model 3 | 1.00 | 0.69 (0.42, 1.12) | 0.98 (0.63, 1.55) | 0.56 (0.32, 0.96) | 0.74 (0.45, 1.23) | 0.17 | 0.97 (0.81, 1.16) |
| Dementia | |||||||
| N. of cases | 32 | 24 | 31 | 22 | 22 | 131 | |
| Model 1 | 1.00 | 0.61 (0.35, 1.06) | 0.84 (0.51, 1.38) | 0.50 (0.28, 0.89) | 0.66 (0.38, 1.14) | 0.13 | 0.96 (0.78, 1.19) |
| Model 2 | 1.00 | 0.62 (0.35, 1.09) | 0.90 (0.54, 1.50) | 0.55 (0.30, 1.01) | 0.69 (0.39, 1.24) | 0.20 | 0.98 (0.79, 1.21) |
| Model 3 | 1.00 | 0.62 (0.35, 1.09) | 0.90 (0.54, 1.50) | 0.54 (0.29, 0.99) | 0.68 (0.38, 1.21) | 0.17 | 0.97 (0.78, 1.21) |
1 1 SD = 0.48% of total fatty acids. CI = confidence interval; Q = quintile; SD = standard deviation. See Table 2 for detailed information on statistical models.