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Binding modes and interaction mechanisms of novel L protein inhibitors. (A) Close-up view into binding mode of (A) A-317491, (C) Khasianine, and (E) VER155008. The main residues involved in the formation of the active site within the structurally conserved RdRp motifs shown in stickes. 2D interaction analysis of (B) A-317491, (D) Khasianine, and (F) VER155008.
