Figure 2.

Schematic representation of the structure of an NiV particle and the viral genome organization. The NiV N, P and L proteins interact with the viral RNA to form the ribonucleoprotein complex, which is surrounded by a lipid bilayer envelope containing the NiV glycoproteins F and G. The NiV M protein is associated with the inner side of the envelope. The viral proteins and arrangement of genes in the viral genome from 3′–5′ are color-coded, respectively, for identification. The NiV P gene products (V, W and C proteins) as a result of mRNA editing are illustrated. The V protein contains a single G insertion, and translation shifts it to +1 reading frame. The W protein contains two G insertions, shifting the translation to the +2 reading frame. The C protein is translated from an internal open reading frame of the P gene.