Skip to main content
. Author manuscript; available in PMC: 2022 Jun 24.
Published in final edited form as: J Med Chem. 2021 Aug 18;64(16):11972–11989. doi: 10.1021/acs.jmedchem.1c00554

Figure 2.

Figure 2.

The variability of the HCV NS3/4A protease S4 subsite. The cocrystal structures of grazoprevir with the (A) GT-1a wild-type NS3/4A protease (PDB 3SUD), (B) GT-1a3a chimera (PDB 6P6Q), (C) R155K (PDB 3SUE), and (D) D168A (PDB 3SUF) protease variants. The catalytic triad (yellow) and residues comprising the S4 pocket (R/T123, R/K155, A156, A157, V158, S/C159, and D/A168 are shown as sticks. The surface of the S4 pocket is outlined in grey.