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. 2022 Jun 16;10(6):963. doi: 10.3390/vaccines10060963

Table 5.

Statistical analyses of the clinical pathology changes from the baseline values in terminal samples of SUDV-challenged animals. To determine statistically significant changes at the time of euthanasia the mean of terminal values were compared to the mean of baseline-value using the Wilcoxon matched-pairs signed ranks tests. Mean values of the complete group of animals (n = 12), of the group of male animals (n = 6) and of the group of female animals (n = 6) have been considered. Differences from baseline were considered to be statistically significant at p-values < 0.05.

Biochemical Analyses
Urea Creatinine ALP ALT AST CK-NAK CRP
Wilcoxon matched-pairs signed rank test p value p value p value p value p value p value p value
Mean values (n = 12) changes from the mean baseline *** 0.0005 *** 0.0005 *** 0.0005 *** 0.001 *** 0.0005 * 0.0269 *** 0.0005
Male mean values changes from the baseline * 0.0313 * 0.0313 * 0.0313 * 0.0313 * 0.0313 * 0.0313 * 0.0313
Female mean values changes from the baseline * 0.0313 * 0.0313 * 0.0313 ns * 0.0313 ns * 0.0313
Hematological Analyses
WBC Monocytes Neutrophils RBC Hematocrit Haemaglobulin Platelets Lymphocytes
Wilcoxon matched-pairs signed rank test p value p value p value p value p value p value p value p value
Mean values (n = 12) changes from the mean baseline ns ns ** 0.0093 *** 0.0005 *** 0.0005 *** 0.0005 *** 0.0005 * 0.0161
Male mean values changes from the baseline ns ns * 0.0313 * 0.0313 * 0.0313 * 0.0313 * 0.0313 ns
Female mean values changes from the baseline ns ns ns * 0.0313 * 0.0313 * 0.0313 * 0.0313 * 0.0313
Coagulation Analyses
ACT PT INR Platelets
Wilcoxon matched-pairs signed rank test p value p value p value p value
Mean values (n = 12) changes from the mean baseline *** 0.0005 * 0.0156 * 0.0313 *** 0.0005
Male mean values changes from the baseline * 0.0313 * 0.0313 ns * 0.0313
Female mean values changes from the baseline * 0.0313 ns ns * 0.0313

Statistically significant changes amongst the entire group of SUDV-exposed animals (n = 12). Statistically significant changes amongst the entire group of males (n = 6). Statistically significant changes amongst the entire group of females (n = 6). No statistically significant changes (ns). Significance level set to p-values: <0.05 (*), <0.01 (**), <0.001 (***), <0.0001 (****).