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. 2022 Jun 9;14(12):2403. doi: 10.3390/nu14122403

Table 1.

Eligibility criteria for studies assessing the effect of non-pharmacological self-management interventions on chemotherapy-induced peripheral neuropathy symptoms and related outcomes in people with advanced cancer.

Inclusion Criteria Exclusion Criteria
Population
  • Advanced cancer: any solid tumor with locally or systemically advanced disease stage (UICC TNM stage III–IV) [26] or any hematological cancer 1

  • Undergoing or have undergone chemotherapy

  • Any age (i.e., adults and children)

  • Studies including people at any cancer stage where results have not been reported separately for those with advanced cancer

Intervention
  • Any non-pharmacological self-management intervention administered by the person with cancer or their caregiver (e.g., exercise, oral nutrition supplements, massage, thermal therapies, meditation), including those initiated with support from a health professional

  • Pharmacological interventions (e.g., prescribed and non-prescribed medications)

  • Eligible non-pharmacological interventions administered in conjunction with pharmacological interventions for CIPN (e.g., duloxetine, gabapentin, pregabalin, carbamazepine, amitriptyline)

  • Non-pharmacological interventions not administered by the person with cancer (e.g., acupuncture, electrical nerve stimulation, scrambler therapy, moxibustion, reflexology, intravenous vitamins)

Comparator
  • Any control (e.g., placebo, usual care)

Outcomes
  • Incidence or severity of CIPN symptoms as measured by any tool

Study design
  • Randomized controlled parallel trials

  • Published in peer-reviewed journals

  • Conference abstracts only

  • Non-randomized controlled trials

  • Narrative/systematic reviews, qualitative studies, protocols, case studies, observational studies

Language
  • English or able to be translated into English

UICC TNM: The Union for International Cancer Control Tumor, Nodes, and Metastases Classification of Malignant Tumors. 1 Studies that referred to ‘advanced cancer’ but do not specify the stage and/or type of cancer were eligible for inclusion.