Table 3.

Results from meta-analyses that were conducted to evaluate the effect of non-pharmacological self-management interventions on chemotherapy-induced peripheral neuropathy symptoms and related outcomes in people with advanced cancer.

Outcome	Pooled Estimate	Significance of Pooled Estimate	Heterogeneity	Number of Studies (Citations)	Sample Size	GRADE Level of Evidence
Physical exercise
CIPN severity	SMD: −0.89, 95% CI: −1.37, −0.41	p = 0.0003	0%	2 [31,34]	76	Moderate
Quality of life	SMD: 0.47, 95% CI: 0.01, 0.93	p = 0.05	0%	2 [31,34]	76	Very low
Physical function	SMD: 0.51, 95% CI: 0.02, 1.00	p = 0.04	42%	3 [31,32,34]	120	Moderate
Endurance	SMD: 1.11, 95% CI: −0.65, 2.87	p = 0.22	93%	2 [31,34]	76	Very low
Emotional wellbeing	SMD: 0.21, 95% CI: −0.42, 0.83	p = 0.52	45%	2 [31,34]	76	Very low
Social wellbeing	SMD: −0.02, 95% CI: −0.53, 0.50	p = 0.95	21%	2 [31,34]	76	Very low
Japanese herbal medicine
CIPN incidence - Grade 1	OR: 1.98, 95% CI: 0.08, 48.14	p = 0.68	92%	2 [39,41]	226	Very low
CIPN incidence - Grade 2	OR: 0.64, 95% CI: 0.06, 6.71	p = 0.71	85%	2 [39,41]	226	Very low
CIPN incidence - Grade 3	OR: 0.37, 95% CI: 0.05, 2.52	p = 0.31	80%	3 [39,40,41]	271	Very low
CIPN incidence - Grade 2 and 3	OR: 0.23, 95% CI: 0.01, 3.89	p = 0.31	89%	3 [39,40,41]	271	Very low
Fatigue	OR: 0.40, 95% CI: 0.06, 2.93	p = 0.37	70%	2 [39,41]	238	Very low
Nausea	OR: 0.80, 95% CI: 0.28, 2.23	p = 0.66	30%	3 [39,40,41]	283	Very low
Vomiting	OR: 0.63, 95% CI: 0.34, 1.16	p = 0.13	0%	3 [39,40,41]	283	Very low
Diarrhoea	OR: 1.20, 95% CI: 0.67, 2.17	p = 0.54	0%	2 [40,41]	231	Very low
Anorexia	OR: 0.71, 95% CI: 0.39, 1.27	p = 0.25	0%	3 [39,40,41]	283	Very low
Relative dose intensity of oxaliplatin	SMD: 1.77, 95% CI: −1.13, 4.68	p = 0.23	98%	2 [39,41]	238	Very low
Side effect: Neutropenia	OR: 0.74, 95% CI: 0.41, 1.31	p = 0.30	0%	3 [39,40,41]	283	Very low
Side effect: Thrombocytopenia	OR: 1.52, 95% CI: 0.87, 2.67	p = 0.14	0%	2 [39,41]	238	Very low