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(A): UV-HPLC chromatograms (330 nm) of iodinated and fluorinated reference compounds (S)-2 and (S)-3; (B): radioactivity-HPLC chromatograms of the corresponding radiotracers (S)-[125I]2 and (S)-[18F]3 obtained after semipreparative RP-HPLC purification and formulation. The radioactivity detector was connected in series after the UV detector, which accounts for the slight difference of retention times (≈ 0.3 min) observed between 125I/127I or 18F/19F products.
