Table 4.
Comparison of enalapril and enalaprilat pharmacokinetic parameters in DCM and CHD patients of same age range.
| Enalapril | Enalaprilat | Enalapril | Enalaprilat | Enalapril | Enalaprilat | ||
|---|---|---|---|---|---|---|---|
| n | AUCtau, ss, norm (ng/mL·h/mg·kg) |
Cmax, ss, norm (ng/mL/mg·kg) |
t-max or tmax, ss (h) |
||||
| Dilated Cardiomyopathy 1 months to <6 year |
20 | 428.3 | 1040.1 | 136.4 | 120.4 | 1.99 | 5.37 |
| (235.5–1338.2) | (0–4468.2) | (44–760.8) | (0–516.3) | (0.93–4.17) | (0–12.02) | ||
| Congenital Heart Disease 1 months to <6 years |
60 | 785.1 | 1166.3 | 261.0 | 142.1 | 1.98 | 6.0 |
| (0–3144.8) | (0–5451.9) | (0–603.5) | (0–719.5) | (0–5.95) | (0–12.2) | ||
| p DCM versus CHD | 0.0025 # | 0.4517 | 0.051 | 0.9543 | 0.7632 | 0.0095 # | |
Data reported as median (range), statistical testing was performed by t-test were used to compare means and their variance, p-values are reported DCM = Dilated Cardiomyopathy; CHD = Congenital Heart Disease, AUC = Area under the curve; Cmax = maximal serum concentrations; tmax = time of maximal serum concentrations; ss = steady state, norm = normalized, # significant based on p adjusted according to Bonferoni.