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Schematic representation of PI3K/AKT/mTOR pathway. GAS5 inhibits the repression of tumor suppressor gene expression such as PTEN, FOXO and p27KIP1 via sponging oncomirs. Pathway was constructed using PathwayMapper [83]. Receptor tyrosine kinase (RTK), Ras homolog enriched in brain (RHEB), Tuberous sclerosis complex 1 and 2 (TSC1 and TSC2).
