Table 3.

Unadjusted comparison of procedure-related predictors of response to faecal microbiota transplantation [FMT] for Clostridioides difficile infection [CDI] among paediatric subjects with inflammatory bowel disease [IBD] [N = 148].

Group [reduction in sample size shown in parentheses]	No response [n = 36]	Response [n = 112]	OR [95% CI]	p  a
Type of delivery				0.18
Sigmoidoscopy/colonoscopy	23 [64%]	82 [73%]	1.12 [0.43 – 2.91]
Capsule	6 [17%]	7 [6%]	0.37 [0.09 – 1.45]
Upper delivery	7 [19%]	23 [21%]	Reference
Frozen stool [vs fresh] [n = 147]	33 [92%]	78 [70%]	0.24 [0.07 – 0.80]	0.02
Local stool bank	10 [28%]	15 [13%]	0.40 [0.16 – 0.99]	0.02
Commercial stool bank	23 [64%]	64 [57%]	0.76 [0.35 – 1.65]	0.45
Patient-selected stool	2 [6%]	34 [30%]	6.06 [1.55 – 23.68]	0.01
Bowel lavage prior to FMT [response n = 110]	26 [72%]	90 [82%]	1.75 [0.73 – 4.18]	0.21
Loperamide use post-FMT [no response n = 35]	9 [26%]	41 [37%]	1.62 [0.70 – 3.76]	0.26
Diarrhoea at time of FMT [prior to colonoscopy preparation] [no response n = 34; response n = 100]	27 [79%]	55 [55%]	0.33 [0.14 – 0.82]	0.02
Abnormal gross appearance of colonoscopy [no response n = 22; response n = 80]	15 [68%]	58 [73%]	1.26 [0.46 – 3.46]	0.66
Number of CDI episodes prior to FMT, median [IQR] [no response n = 33, response n = 110]	4 [3, 5]	3 [3, 4]	0.86 [0.71 – 1.03]	0.09
Months from CDI diagnosis until FMT [no response n = 31; response n = 111]	15 [7, 26]	8 [5, 14]	0.97 [0.95 – 0.99]	0.02

OR, odds ratio; CI, confidence interval; IQR, interquartile range.

^a  pvalue from unadjusted logistic regression.