Table 4.
Correlation between bowel wall thickness and clinical factors [see separate file]
| Factor | Levels | N | Lamina propria thickness | Muscularis mucosa thickness | Submucosa thickness | Muscularis propria thickness | Total wall thickness | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Statistics | p-value | Statistics | p-value | Statistics | p-value | Statistics | p-value | Statistics | p-value | |||
| Gender | Male | 38 | 680.06 [539.47, 867.12] | 0.298 | 108.42 [78.67, 154.81] | 0.513 | 1950.00 [1644.97, 2439.53] | 0.562 | 1626.71 [1494.19, 2028.34] | 0.964 | 4629.52 [3882.00, 5182.67] | 0.356 |
| Female | 23 | 648.17 [534.19, 702.50] | 108.50 [66.08, 127.50] | 1925.88 [1649.50, 2239.92] | 1592.25 [1504.17, 2099.83] | 4435.00 [3953.92, 4768.58] | ||||||
| Family history | ||||||||||||
| CD | Yes | 6 | 598.67 [502.00, 646.96] | 0.324 | 113.25 [54.67, 119.33] | 0.622 | 1845.67 [1769.17, 1915.54] | 0.522 | 1670.42 [1519.67, 1824.67] | 0.605 | 4432.00 [3956.08, 4857.42] | 0.538 |
| No | 54 | 670.92 [539.47, 811.17] | 100.92 [74.50, 146.75] | 1958.83 [1627.50, 2380.62] | 1626.71 [1490.62, 2095.38] | 4549.50 [3913.75, 5161.58] | ||||||
| UC | Yes | 12 | 656.94 [489.58, 728.38] | 0.318 | 105.67 [77.00, 122.25] | 0.897 | 2009.92 [1516.98, 2565.30] | 0.882 | 2108.17 [1793.78, 2259.04] | 0.009 | 4907.42 [4300.17, 5563.50] | 0.155 |
| No | 48 | 670.42 [548.16, 833.19] | 106.08 [72.53, 156.50] | 1934.44 [1671.91, 2304.69] | 1589.54 [1455.29, 1984.79] | 4495.19 [3896.83, 5062.75] | ||||||
| Smoker | Current | 1 | 497.33 [497.33, 497.33] | 0.244 | 51.33 [51.33, 51.33] | 0.179 | 1212.17 [1212.17, 1212.17] | 0.16 | 2118.17 [2118.17, 2118.17] | 0.269 | 3895.67 [3895.67, 3895.67] | 0.355 |
| Ex smoker | 0 | - | - | - | - | - | ||||||
| Never | 57 | 661.50 [543.50, 812.67] | 108.75 [78.17, 151.25] | 1957.00 [1689.00, 2404.12] | 1621.67 [1486.33, 2034.62] | 4550.00 [3945.00, 5126.83] | ||||||
| EIM | ||||||||||||
| Joint | Yes | 6 | 701.65 [578.41, 852.67] | 0.645 | 117.08 [90.67, 189.38] | 0.265 | 2173.56 [1897.88, 2975.66] | 0.153 | 1708.44 [1573.25, 2128.09] | 0.529 | 5087.83 [4306.62, 5875.29] | 0.208 |
| No | 55 | 660.17 [534.19, 789.33] | 108.50 [69.31, 142.25] | 1925.88 [1618.08, 2290.94] | 1621.67 [1494.92, 2051.65] | 4513.50 [3899.50, 5031.27] | ||||||
| Skin | Yes | 1 | 704.88 [704.88, 704.88] | 0.65 | 108.75 [108.75, 108.75] | 0.955 | 1325.88 [1325.88, 1325.88] | 0.173 | 1681.62 [1681.62, 1681.62] | 0.91 | 3800.38 [3800.38, 3800.38] | 0.256 |
| No | 60 | 659.65 [535.16, 808.17] | 106.08 [72.53, 152.44] | 1950.00 [1671.91, 2333.62] | 1619.40 [1499.21, 2071.88] | 4549.50 [3934.58, 5079.61] | ||||||
| Eye | Yes | 0 | - | NA | - | NA | - | NA | - | NA | - | NA |
| No | 61 | 660.17 [536.12, 806.67] | 108.50 [73.33, 151.25] | 1943.00 [1631.50, 2310.12] | 1621.67 [1503.50, 2068.67] | 4549.00 [3903.33, 5063.88] | ||||||
| Bone | Yes | 0 | - | NA | - | NA | - | NA | - | NA | - | NA |
| No | 61 | 660.17 [536.12, 806.67] | 108.50 [73.33, 151.25] | 1943.00 [1631.50, 2310.12] | 1621.67 [1503.50, 2068.67] | 4549.00 [3903.33, 5063.88] | ||||||
| Anaemia | Yes | 26 | 700.50 [636.12, 867.12] | 0.066 | 93.92 [65.28, 117.44] | 0.027 | 2070.33 [1615.38, 2502.75] | 0.531 | 1727.81 [1506.04, 2107.62] | 0.737 | 4579.19 [3913.75, 5171.08] | 0.705 |
| No | 35 | 607.33 [527.79, 733.67] | 117.25 [83.08, 177.50] | 1925.88 [1716.08, 2225.83] | 1616.50 [1494.92, 1999.58] | 4513.50 [3940.92, 4916.00] | ||||||
| PSC | Yes | 1 | 705.50 [705.50, 705.50] | 0.609 | 53.33 [53.33, 53.33] | 0.211 | 2454.50 [2454.50, 2454.50] | 0.307 | 1395.00 [1395.00, 1395.00] | 0.281 | 4599.83 [4599.83, 4599.83] | 0.91 |
| No | 60 | 659.65 [535.16, 808.17] | 108.62 [76.83, 152.44] | 1934.44 [1630.17, 2304.69] | 1626.71 [1504.50, 2071.88] | 4531.25 [3901.42, 5079.61] | ||||||
| None | Yes | 29 | 590.00 [523.33, 700.12] | 0.025 | 117.50 [85.00, 169.67] | 0.044 | 1918.50 [1626.17, 2160.67] | 0.133 | 1617.12 [1503.50, 1989.67] | 0.74 | 4476.88 [3877.33, 4902.17] | 0.333 |
| No | 32 | 703.62 [628.12, 879.21] | 93.92 [66.51, 118.93] | 2070.33 [1671.91, 2543.94] | 1656.69 [1493.12, 2116.79] | 4604.10 [3934.58, 5252.79] | ||||||
| Backwash ileitis | Yes | 13 | 702.38 [551.75, 949.00] | 0.302 | 117.62 [68.50, 156.50] | 0.823 | 2302.88 [2180.00, 2498.50] | 0.019 | 1557.12 [1486.33, 1983.17] | 0.206 | 4732.50 [4476.88, 5185.83] | 0.129 |
| No | 47 | 654.75 [537.12, 745.00] | 108.50 [79.17, 141.71] | 1906.67 [1570.19, 2238.92] | 1681.62 [1513.71, 2117.25] | 4435.00 [3886.50, 5031.27] | ||||||
| Extent of colitis | Extensive | 58 | 659.65 [536.62, 811.17] | 0.92 | 109.71 [74.50, 154.81] | 0.171 | 1950.00 [1644.97, 2380.62] | 0.333 | 1619.40 [1503.83, 2060.16] | 0.739 | 4549.50 [3913.75, 5111.09] | 0.35 |
| Left- sided | 3 | 723.17 [564.67, 747.58] | 80.17 [58.08, 94.33] | 1784.67 [1443.02, 1950.08] | 2009.50 [1641.58, 2071.56] | 4148.25 [3816.29, 4525.21] | ||||||
| Proctitis | 0 | - | - | - | - | - | ||||||
| Medications prior to colectomy | ||||||||||||
| Immunomodulators | Yes | 44 | 649.29 [532.93, 744.58] | 0.095 | 106.08 [79.67, 139.44] | 0.513 | 1934.44 [1671.91, 2248.17] | 0.292 | 1782.58 [1550.29, 2104.08] | 0.015 | 4574.92 [4016.41, 5062.75] | 0.827 |
| No | 14 | 696.77 [651.17, 945.33] | 97.75 [69.71, 119.59] | 2367.17 [1591.00, 2976.17] | 1481.42 [1272.04, 1665.34] | 4677.17 [3702.97, 5278.96] | ||||||
| Anti-TNF | Yes | 37 | 679.33 [543.50, 812.67] | 0.616 | 115.83 [85.00, 158.83] | 0.021 | 1960.67 [1743.17, 2404.12] | 0.763 | 1770.00 [1549.67, 2068.67] | 0.308 | 4671.67 [4074.67, 5063.88] | 0.263 |
| No | 20 | 658.12 [548.34, 751.00] | 81.50 [66.62, 116.97] | 1941.44 [1574.91, 2353.20] | 1539.88 [1291.35, 2167.80] | 4199.92 [3854.06, 5216.88] | ||||||
| Vedolizumab | Yes | 1 | 463.67 [463.67, 463.67] | 0.175 | 86.17 [86.17, 86.17] | 0.546 | 1846.83 [1846.83, 1846.83] | 0.651 | 2100.00 [2100.00, 2100.00] | 0.366 | 4676.17 [4676.17, 4676.17] | 0.88 |
| No | 22 | 657.42 [537.06, 826.23] | 111.92 [79.88, 166.96] | 1912.58 [1748.38, 2308.31] | 1706.42 [1547.67, 2069.78] | 4640.02 [4104.08, 5182.67] | ||||||
| Medications at time of colectomy | Yes | 13 | 659.12 [532.25, 812.67] | 0.846 | 96.00 [78.17, 158.83] | 0.805 | 1882.83 [1743.17, 2302.88] | 0.846 | 1592.25 [1447.17, 1800.38] | 0.428 | 4549.00 [4074.67, 5002.50] | 0.972 |
| 5-ASA | No | 48 | 661.33 [537.62, 780.67] | 109.71 [72.53, 137.75] | 1958.83 [1602.41, 2345.43] | 1725.56 [1508.46, 2086.12] | 4556.67 [3901.42, 5079.61] | |||||
| Systemic steroids | Yes | 53 | 662.50 [543.50, 812.67] | 0.114 | 103.67 [70.12, 133.25] | 0.347 | 1943.00 [1631.50, 2310.12] | 0.966 | 1621.67 [1458.00, 2034.62] | 0.393 | 4549.00 [3877.33, 5063.88] | 0.358 |
| No | 8 | 535.75 [418.75, 687.34] | 119.50 [84.17, 169.62] | 2052.17 [1660.47, 2310.28] | 1708.44 [1549.38, 2108.41] | 4594.83 [4208.44, 5225.12] | ||||||
| 6MP | Yes | 6 | 605.44 [540.03, 688.75] | 0.716 | 90.15 [47.44, 116.23] | 0.175 | 2210.69 [1959.62, 2378.81] | 0.298 | 1958.35 [1793.47, 2145.52] | 0.069 | 4805.44 [4509.75, 5047.41] | 0.235 |
| No | 55 | 661.50 [535.19, 809.67] | 108.50 [78.08, 156.25] | 1925.88 [1618.08, 2294.56] | 1616.50 [1472.17, 2022.06] | 4513.50 [3886.50, 5095.35] | ||||||
| · AZA | Yes | 7 | 888.83 [692.33, 1174.50] | 0.037 | 86.33 [72.42, 140.67] | 0.635 | 2180.00 [2029.25, 2373.08] | 0.23 | 2009.50 [1627.92, 2051.65] | 0.556 | 5173.17 [4726.08, 5688.92] | 0.067 |
| No | 54 | 651.46 [533.22, 745.42] | 109.71 [74.50, 146.75] | 1912.58 [1615.38, 2308.31] | 1616.81 [1503.83, 2061.28] | 4455.94 [3897.58, 5001.92] | ||||||
| MTX | Yes | 9 | 590.00 [543.50, 812.67] | 0.555 | 110.67 [81.17, 117.50] | 0.887 | 1882.83 [1764.00, 2160.67] | 0.76 | 1891.67 [1558.83, 2000.62] | 0.36 | 4650.67 [3877.33, 4912.67] | 0.871 |
| No | 52 | 662.00 [535.16, 780.67] | 103.33 [69.72, 156.12] | 1958.83 [1622.12, 2415.93] | 1616.81 [1479.25, 2071.88] | 4531.25 [3934.58, 5138.42] | ||||||
| Vedolizumab | Yes | 0 | - | NA | - | NA | - | NA | - | NA | - | NA |
| No | 61 | 660.17 [536.12, 806.67] | 108.50 [73.33, 151.25] | 1943.00 [1631.50, 2310.12] | 1621.67 [1503.50, 2068.67] | 4549.00 [3903.33, 5063.88] | ||||||
| Anti-TNF | Yes | 14 | 702.06 [601.38, 991.31] | 0.237 | 92.42 [65.28, 144.15] | 0.461 | 2021.75 [1705.03, 2400.42] | 0.891 | 1587.67 [1433.00, 1861.25] | 0.493 | 4574.92 [3883.83, 5283.04] | 0.918 |
| No | 47 | 659.12 [527.79, 745.00] | 108.75 [79.08, 144.62] | 1943.00 [1628.83, 2306.50] | 1631.75 [1504.17, 2090.75] | 4513.50 [3974.75, 5063.12] | ||||||
| Sulphasalizine | Yes | 1 | 523.33 [523.33, 523.33] | 0.334 | 503.33 [503.33, 503.33] | 0.088 | 1876.67 [1876.67, 1876.67] | 0.733 | 1447.17 [1447.17, 1447.17] | 0.307 | 4333.83 [4333.83, 4333.83] | 0.776 |
| No | 60 | 660.83 [537.62, 808.17] | 106.08 [72.53, 137.75] | 1950.00 [1630.17, 2333.62] | 1626.71 [1504.50, 2071.88] | 4549.50 [3901.42, 5079.61] | ||||||
| Cyclosporine | Yes | 3 | 700.12 [680.81, 701.25] | 0.641 | 96.00 [90.50, 114.62] | 0.96 | 1631.50 [1628.83, 1778.69] | 0.286 | 1486.33 [1391.79, 1521.73] | 0.133 | 4004.50 [3932.75, 4012.44] | 0.152 |
| No | 58 | 656.94 [533.22, 811.17] | 108.62 [70.93, 154.81] | 1958.83 [1686.28, 2380.62] | 1656.69 [1506.04, 2078.29] | 4574.92 [3913.75, 5111.09] | ||||||
| Tacrolimus | No | 60 | 659.65 [535.16, 808.17] | 0.776 | 108.62 [76.83, 152.44] | 0.281 | 1950.00 [1630.17, 2333.62] | 0.427 | 1619.40 [1499.21, 2043.14] | 0.233 | 4531.25 [3901.42, 5079.61] | 0.865 |
| Yes | 1 | 698.62 [698.62, 698.62] | 67.12 [67.12, 67.12] | 1685.38 [1685.38, 1685.38] | 2155.25 [2155.25, 2155.25] | 4608.38 [4608.38, 4608.38] | ||||||
| Duration of immunomodulators | 29 | -0.10 [-0.45, 0.27] | 0.59 | 0.15 [-0.23, 0.49] | 0.45 | 0.14 [-0.24, 0.48] | 0.46 | 0.19 [-0.19, 0.52] | 0.32 | 0.06 [-0.31, 0.42] | 0.75 | |
| Duration of anti-TNF | 28 | -0.15 [-0.50, 0.23] | 0.44 | 0.15 [-0.23, 0.50] | 0.44 | -0.03 [-0.40, 0.35] | 0.88 | 0.07 [-0.31, 0.43] | 0.73 | -0.12 [-0.47, 0.26] | 0.54 |
CD, Crohn’s disease; UC, ulcerative colitis; PSC, primary sclerosing cholangitis; 5- ASA, 5-aminosalicylic acid, 6MP, mercaptopurine; AZA, azathioprine; MTX, methotrexate; TNF, tumour necrosis factor; NA, not available; EIM, extraintestinal manifestations.