ATM	Ataxia-telangiectasia mutated;
DNA	deoxyribonucleic acid;
GCLC	glutamyl-cysteine ligase catalytic subunit;
GCLM	glutamyl-cysteine ligase modifier subunit;
GRE	genetic suppressor element;
GSH	glutathione;
GSR	glutathione reductase;
GSS	glutathione synthetase;
IL	interleukin;
iPSCs	induced pluripotent stem cells;
KAP1	KRAB-associated protein 1;
KEAP1	Kelch-like ECH-associated protein 1;
mRNA	messenger ribonucleic acid;
NF-kB	nuclear factor kappa-light-chain-enhancer of activated B cells;
NRF2	nuclear factor erythroid 2–related factor 2;
OGG1	8-oxoguanine DNA glycosylase-1;
ROS	reactive oxygen species;
SOD	superoxide dismutase;
TERT	telomerase reverse transcriptase;
γ-H2A.X	gamma-H2A histone family member X;
2DG	deoxy-D-glucose;
8-oxoG	8-oxoguanineAkt, protein kinase B;
AMPK	AMP-activated protein kinase;
ARE	antioxidant response element;
ATP	adenosine triphosphate;
Bax	Bcl2 associated X;
Bcl-2	B-cell lymphoma 2;
BSO	L-buthionine (S,R)-sulfoximine;
CAT	catalase;
COX1	cytochrome c oxidase I;
DRG	dorsal root ganglion;
FAC	ferric ammonium citrate;
FXN	frataxin;
GCL	γ-glutamyl cysteine ligase;
GCLC	glutamyl-cysteine ligase catalytic subunit;
GCLM	glutamyl-cysteine ligase modifier subunit;
GPX4	glutathione peroxidase 4;
GRP75	glucose-regulated protein 75;
GSH	glutathione;
GSSG	oxidised glutathione;
HO-1	heme oxygenase 1;
iPSCs	induced pluripotent stem cells;
ISC	iron-sulfur clusters;
ISCU	iron-sulfur cluster assembly enzyme;
KEAP1	Kelch-like ECH-associated protein 1;
KIKO	knock-in/knock-out;
MMP	mitochondrial membrane potential;
mRNA	messenger ribonucleic acid;
mTFA	mitochondrial transcription factor A;
mTOR	mammalian target of rapamycin;
NDUFS3	NADH: ubiquinone oxidoreductase core subunit s3;
NE	not evaluated;
NF-kB	nuclear factor kappa-light-chain-enhancer of activated B cells;
NQO1	NAD(P)H quinone oxidoreductase 1;
NRF1	nuclear respiratory factor 1;
NRF2	nuclear factor erythroid 2–related factor 2;
NSCs	neural stem cells;
OGDH	8-oxoglutarate dehydrogenase E1 component;
PDH	pyruvate dehydrogenase;
PGC-1α	peroxisome proliferator-activated receptor-γ (PPARγ) coactivator 1 alpha;
ROS	reactive oxygen species;
RSL-3	RAS-selective lethal 3;
SDH-A	succinate dehydrogenase complex, subunit A;
SOD	superoxide dismutase;
TERT	telomerase reverse transcriptase;
4-HNE	4-hydroxynonenal;
8-oxodG	8-oxo-2′-deoxyguanosine