Table 1.
Inhibitory activity against pseudoviruses pseudotyped with S protein of Wuhan lineages B and Delta lineage B.1.617.2.
| Compound | CC50 a | Wuhan Lineages B | Delta Lineage B.1.617.2 | ||
|---|---|---|---|---|---|
| µM | IC50 b µM | SI c | IC50 b µM | SI c | |
| 1 | 2950 | >500 | - | NT d | − |
| 2 | 1260 | >500 | - | NT | − |
| 3 | 1260 | >500 | - | NT | − |
| 4 | 1080 | >440 | - | NT | − |
| 5 | 660 | >200 | - | NT | − |
| 6 | 982 | 188.6 ± 21.1 | 5 | NT | − |
| 7 | 1455 | >500 | - | NT | − |
| 8 | 1045 | >500 | - | NT | − |
| 9 | 346 | >200 | - | NT | − |
| 10 | 362 | 15.6 ± 2.1 | 23 | >100 | − |
| 11 | 186 | 17.7 ± 3.2 | 10 | 16.0 ± 4.5 | 11 |
| 12 | 396 | 21.3 ± 4.3 | 18 | >100 | − |
| 13 | 960 | >200 | - | NT | − |
| 14 | 540 | >200 | - | NT | − |
| 15 | 538 | >200 | - | NT | − |
| 16 | 350 | >200 | - | NT | − |
| 17 | 855 | >200 | - | NT | − |
| 18 | 292 | 17.7 ± 3.7 | 17 | >100 | − |
| 19 | 1015 | >200 | NT | − | |
| 20 | 935 | >200 | NT | − | |
| 21 | 743 | 25.8 ± 4.2 | 29 | 14.2 ± 2.9 | 53 |
| 22 | 407 | >200 | - | NT | − |
| 23 | 350 | >200 | - | NT | − |
| 24 | 348 | 155 | 2 | NT | − |
| 25 | 438 | 196 | 2 | NT | − |
| 26 | 179 | 59.8 ± 7.1 | 3 | NT | − |
| 27 | 166 | 52.6 ± 8.3 | 3 | NT | − |
| 28 | 1080 | 190 | 5 | NT | − |
| 29 | 490 | >200 | - | NT | − |
| 30 | 417 | 41.2 ± 5.2 | 10 | >100 | − |
| 31 | 1525 | 156 | 9 | NT | − |
| 32 | 820 | >200 | - | NT | − |
| 33 | 2160 | >200 | - | NT | − |
| 34 | 1140 | >200 | - | NT | − |
| 35 | 1260 | 190 | 6 | NT | − |
| Arbidol | 14.8 | 7.8 ± 3.1 | 2 | NT | − |
a CC50 is the cytotoxic concentration, the concentration resulting in the death of 50% of cells; b IC50 is the 50% virus-inhibiting concentration, the concentration leading to 50% inhibition of virus replication; c SI is the selectivity index, the ratio of CC50/IC50. The data presented are the mean of three independent experiments. The values for CC50 and IC50 are presented as the mean ± error of the experiment. d NT: no testing.