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. 2022 Jun 16;14(6):1283. doi: 10.3390/pharmaceutics14061283

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© 2022 by the author.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Brain drug delivery by convection-enhanced diffusion. (A) Concentration of GDNF in primate brain at 1–7 mm removed from the CED catheter. Derived from data reported by Salvatore et al. [131] and reproduced with permission from [132], Copyright© 2010 Taylor and Francis. Original GDNF concentrations, in pg per mg protein, were converted to ng per gram brain, based on 100 mg protein per gram brain [133]. (B,C) Glial fibrillary acidic protein (GFAP) immunohistochemistry of monkey brain following CED administration of GDNF. Magnification bar is 1 mm in (B) and 50 microns in (C). Reproduced with permission [134], Copyright© 2003 John Wiley & Sons.