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. 2022 Jun 16;14(6):1283. doi: 10.3390/pharmaceutics14061283

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© 2022 by the author.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Identification of BBB RMT targets by immunohistochemistry of brain. (A) Immunohistochemistry of rat brain with an antibody to all isoforms LEPR. Reproduced with permission from [596], Copyright© 1998 John Wiley & Sons. (B) Expression of INSR, TfR1, IGFR, and LEPR on both the brain endothelium and on brain cells. In contrast, immunohistochemistry shows receptors such as LRP1, LDLR, NMDAR, and nAChR are expressed on brain cells but not endothelium. Reproduced from [525], Copyright© 2020 licensed under Creative Commons Attribution License (CC-BY).