Figure 23.

Propranolol binding to brain tissue proteins. The BUI at 1, 2, or 4 min after injection, BUI(t), relative to the BUI at T = 0, is plotted against the time after carotid artery injection. The data were fit to a compartmental model of efflux and tissue binding similar to that shown in Figure 19, which allowed for determination of the rate constant of drug association (K₅) and the rate constant of drug dissociation (K₆) from tissue binding proteins. The closed circles are the experimentally determined BUI values, and the open circles are the BUI values predicted from fitting these data to the model of drug efflux and binding in brain. Reproduced in part with permission from [1145], Copyright© 1984 American Physiological Society.