Figure 3.

Accumulated mutations in the S early VOCs. (A,B) Amino acid substitutions are shown in the S domain organization (A) and depicted in the one-RBD-up structure (B) of the S Alpha variant (PDB ID 7EDF). Amino acid substitutions are highlighted in two different RBD-oriented protomers (RBD-up and RBD-down). The dotted lines indicate the mutated amino acid residues which are not resolved in the structure. (C,D) Illustrations as in (A) and (B), respectively, for the S Beta variant (PDB ID 7VX1). (E,F) Illustrations as in (A/C) and (B/D), respectively, for the S Gamma variant (PDB ID 7SBS).