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Accumulated mutations in the S Delta and Omicron variants. (A,B) Amino acid substitutions are shown in the S domains (A) and depicted in the one-RBD-up structure (B) of the S Delta variant (PDB ID 7SBL). Mutated amino acid residues are highlighted in the RBD-up and RBD-down protomers. The dotted lines indicate the mutated amino acid residues which are not resolved in the structure. (C,D) Illustrations as in (A,B), respectively, for the S Omicron variant (PDB ID 7TEI).
