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. 2022 Jun 23;22:692. doi: 10.1186/s12885-022-09736-5

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 11 — Currently available drugs that target COL1A1, COL5A1, and ITGA4. Drugs (shown with blue squares) listed in DrugBank and Drug-gene interaction database that target COL1A1, COL5A1, or ITGA4 (shown with orange circles). Among the ITGA4 targeting drugs, the action of abrilumab, and vedolizumab, which are shown in light blue, are specific to integrin α4β7 rather than integrin α4β1. Natalizumab, firategrast, and BIO-1211 target integrin α4