Table 1.
Functional annotation clustering of 83 differentially expressed genes in gastric cancer. Analysis was performed with the highest classification stringency in DAVID (ECM: Extracellular Matrix, GOTERM: Gene Ontology Term, GOTERM BP: GO-biological process, GOTERM MF: GO-molecular function, and GOTERM CC: GO-cellular compartment, KEGG Pathway: Pathways listed in Kyoto Encyclopedia of Genes and Genomes)
| Annotation Cluster 1 | Enrichment Score: 7.26 | Count | Genes | P-Value | Benjamini |
| KEGG Pathway | ECM-receptor interaction | 12 | COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL5A1, COL5A2, COL6A3, FN1, SPP1, THBS1, THBS2 | 2.2E-11 | 1.6E-9 |
| KEGG Pathway | Focal adhesion | 12 | 2.2.E-7 | 5.2E-6 | |
| KEGG Pathway | PI3K-Akt signaling pathway | 12 | 3.4E-5 | 4.0E-4 | |
| Annotation Cluster 2 | Enrichment Score: 6.68 | Count | P-Value | Benjamini | |
| GOTERM BP DIRECT | Negative regulation of growth | 6 |
MT1E, MT1F, MT1G, MT1H, MT1M, MT1X |
2.4E-8 | 3.1E-6 |
| GOTERM BP DIRECT | Cellular response to zinc ion | 6 | 2.4E-8 | 3.1E-6 | |
| KEGG Pathway | Mineral absorption | 6 | 1.6E-5 | 2.3E-4 | |
| Annotation Cluster 3 | Enrichment Score: 1.25 | Count | P-Value | Benjamini | |
| GOTERM MF DIRECT | Oxygen binding | 3 | CYP2C18, CYP2C9, CYP3A5 | 2.0E-2 | 2.4E-1 |
| GOTERM MF DIRECT | Oxidoreductase activity, acting on paired donors with incorporation or reduction of molecular oxygen | 3 | 2.9E-2 | 2.9E-1 | |
| GOTERM MF DIRECT | Monooxygenase activity | 3 | 2.9E-2 | 2.9E-1 | |
| GOTERM CC DIRECT | Organelle membrane | 3 | 5.9E-2 | 3.2E-1 | |
| KEGG Pathway | Retinol metabolism | 3 | 8.1E-2 | 4.8E-1 | |
| GOTERM MF DIRECT | Heme binding | 3 | 1.3E-1 | 6.7E-1 | |
| GOTERM MF DIRECT | Iron ion binding | 3 | 1.6E-1 | 7.8E-1 |