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Calculated logP and logD7.4 of Compound A and various small molecules KOR antagonists.
| Ligand | clogP a | clogD7.4a |
|---|---|---|
| Compound A | 4.2 | 4.09 |
| nor-BNI | 3.13 | 1.55 |
| 5′-GNTI | 1.72 | −0.55 |
| JDTic | 3.43 | 1.78 |
| JNJ-67953964 | 4.97 | 3.24 |
| CYM-53003/BTRX-335140 | 3.82 | 2.37 |
a Calculated using Percepta software (version 2021, ACD/Labs, Toronto, Canada) [62].
