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. Author manuscript; available in PMC: 2022 Aug 1.
Published in final edited form as: Mol Cancer Ther. 2021 Dec 5;21(2):371–381. doi: 10.1158/1535-7163.MCT-21-0358

Figure 4. Abdominopelvic CONV and FLASH irradiation in combination with αPD-1 therapy enhance intratumoral CD8+ infiltration and decrease the Treg to T effector ratio in the ID8 ovarian tumor microenvironment.

Figure 4.

Flow cytometry analysis for lymphocytes (CD45+), T cells (TCRβ+), CD4+, CD8+, and Treg (CD4+ FoxP3+) infiltration, Ki-67+ proliferation, and CD107a+ staining in the tumor bearing omentum at 96 hours and 17 days post irradiation (n= 5 mice per group). *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001 compared by one-way ANOVA followed by Tukey’s multiple comparisons post-hoc test. Error bars represent standard deviation of the mean. At least 2 independent experiments showed similar results.