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. 2022 Jun 14;14(6):1293. doi: 10.3390/v14061293

Figure 3.

Figure 3

Antigenic site-specific nAb responses vary by age/exposure history. Surveillance sera from children ages ≤ 5 years (n = 65) (A) and adults ≥ 15 years (n = 21) (B) were evaluated for nAb antibody titer to GII.4 2012 Sydney, GII.4 1987 Camberwell, and antigenic site-chimera VLP comprised of GII.4 2012 Sydney antigenic sites in the backbone of GII.4 1987 Camberwell. Only samples with titer ≥ 50 to either GII.4 2012 Sydney or 1987 Camberwell were included in analyses to exclude subjects who are genetically resistant to GII.4 infection. Y-axis: reciprocal of the serum dilution at 50% inhibitory dose. Marker: one individual. Line: geometric mean titer. Error bars: 95% confidence intervals. Dashed line: limit of detection. * p = 0.02, ** p = 0.004, **** p < 0.0001 compared to GII.4 1987 Camberwell.