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. 2022 Jun 2;12(6):516. doi: 10.3390/metabo12060516

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Transcript variants and protein isoforms of human and murine Nceh1. (A) The human NCEH1 gene transcribes into 4 different transcript variants (TV) generated by alternative splicing or translation start codon usage ranging from 4307 to 4560 bp. Transcript variants vary in the 5′ and 3′ untranslated region (UTR) and coding sequence (CDS). The murine Nceh1 gene transcribes into a single 4394 bp long mRNA. (B) Human protein isoform A consists of 416 amino acids (aa). Isoform B is lacking 8 aa (position 123–130), leading to a shorter 408 aa protein. Isoform C is lacking 141 aa at the N-terminus, leading to the shortest protein consisting of 275 aa. The murine Nceh1 gene encodes for a single protein isoform consisting of 408 aa.