Table 2.

Phenotypical changes in KIAA1363-ko mice.

Proposed Function	Phenotypical Change	Reference
organophosphate detoxification	60–90% reduced [3H]chlorpyrifos oxon-hydrolysis in KIAA1363-ko brain, heart, spinal cord, kidney, lung, muscle, and testis membrane fractions; chlorpyrifos injection markedly increased tremoring, acetylcholine-esterase inhibition, and 48 h mortality in KIAA1363-ko mice; parathion injection dramatically increased tremoring and acute mortality in KIAA1363-ko mice.	Nomura et al., 2005 [23] Nomura et al., 2006 [19] Nomura et al., 2008 [33]
2-acetyl monoalkylglycerol ether hydrolysis	25–95% reduced 2-acetyl monoalkylglycerol ether hydrolase activity in whole homogenates and membrane fractions of KIAA1363-ko brain, heart, lung, testis, and kidney, as well as in lysates of KIAA1363-deficient murine peritoneal macrophages; no differences in brain monoalkylglycerol ether levels.	Nomura et al., 2006 [19] Buchebner et al., 2010 [34]
neutral cholesterol ester hydrolysis	30–50% reduced neutral cholesterol ester hydrolase activity and impaired cellular cholesterol ester degradation in KIAA1363-deficient murine peritoneal macrophages; adrenal gland enlargement and elevated cholesterol ester levels in KIAA1363-ko mice; unchanged neutral cholesterol ester hydrolase activity and cholesterol ester levels in tissues of KIAA1363-ko mice; KIAA1363/apolipoprotein E and KIAA1363/low-density lipoprotein receptor double-ko mice show accelerated development of atherosclerosis.	Sekiya et al., 2009 [35] Buchebner et al., 2010 [34] Ohta et al., 2011 [20]