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. 2022 Jun 6;15(6):721. doi: 10.3390/ph15060721

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Comparison of radioprotective effect between CY-TMP 1 and Amifostine (Ami) on L-02 cells. (a) The total intracellular ROS induced by X-ray radiation were probed with Reactive Oxygen Species Assay Kit and (b) quantitatively measured 24 h after radiation. (c) Fluorescence imaging and (d) quantitative analysis of comet tail as an index of DNA damage. (e) Fluorescence imaging and (f) quantitative analysis of γ-H2A.X based on immunofluorescent staining. Compared to the 6 Gy radiation group, CY-TMP1 significantly decreases radiation-induced ROS level and DNA damage (n = 6, mean ± SD, ** p < 0.01). Compared to the Ami-treated group, CY-TMP1 also exhibits significantly higher efficiency in ROS-scavenging ability and reducing the ratio of DNA double chain breaks induced by ionizing radiation (n = 6, mean ± SD, ** p < 0.01).