Figure 2.

Biodistribution of ⁸⁹Zr-labeled GMP-grade exosomes in mice imaged using PET/CT. (a) Biodistribution of i.v.-administered ⁸⁹Zr-Exo in mice was evaluated using PET/CT imaging, and the values are shown as the %ID/g at various time points. (b) Whole-body fraction of ⁸⁹Zr-Exo in various organs of mice (n = 6) was determined by a volume-of-interest analysis of the PET/CT image, and the values are shown as the %ID at various time points. (c) Time-course distribution of ⁸⁹Zr-Exo was shown in each organ as the %ID with standard error of mean (SEM). (d) Time-course distribution of ⁸⁹Zr-Exo in male (n = 3) and female (n = 3) mice was shown in each organ as the %ID with SEM.