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. 2022 May 24;14(6):1118. doi: 10.3390/pharmaceutics14061118

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Biodistribution of ⁸⁹Zr-labeled GMP-grade exosomes in rats imaged by PET/CT. (a) Biodistribution of i.v.-administered ⁸⁹Zr-Exo in rat was evaluated at various time points through PET/CT imaging, with the results shown as the %ID/g. (b) Whole-body fraction of ⁸⁹Zr-Exo in various organs of rat (n = 6) was assessed by a volume-of-interest analysis of the PET/CT image, with the results shown as the %ID at various time points. (c) Time-course distribution of ⁸⁹Zr-Exo in each organ was shown as the %ID with SEM. (d) Time-course distribution of ⁸⁹Zr-Exo in male (n = 3) and female (n = 3) rats was shown in each organ as the %ID with SEM.