Figure 5.

Biodistribution and blood PK of ⁸⁹Zr-labeled GMP-grade exosomes in rats based on ex vivo gamma-counting analysis. (a) Schematic of the ex vivo gamma-counting analysis of the distribution of i.v.-administered ⁸⁹Zr-Exo in various organs and tissues of rats. (b) Whole-body fraction of ⁸⁹Zr-Exo in various organs of rats (n = 4 for each time point) was determined using a gamma-counting assay, with the results shown as the %ID at various time points. (c) Time-course distribution of ⁸⁹Zr-Exo obtained using a gamma-counting assay in each organ was shown as the %ID with SEM. (d) Time-course distribution of ⁸⁹Zr-Exo in the blood, urine, muscle, and femur was shown as the %ID/g with SEM due to differences in the sampling methods. (e) Time-course distribution of ⁸⁹Zr-Exo and free ⁸⁹Zr-DFO in the blood was shown as the %ID with SEM.