Table 4.
Ex vivo pharmacokinetic parameters of 89Zr-Exo following i.v. administration in various organs of SD rats.
| Organ | Cmax [%ID] | Tmax [d] | AUC0-t [%ID × d] |
|---|---|---|---|
| Liver | 38.13 | 2.00 | 256.82 |
| Spleen | 3.19 | 0.25 | 18.73 |
| Brain | 0.02 | 2.00 | 0.11 |
| Small intestine | 6.77 | 0.08 | 2.22 |
| Large intestine | 7.91 | 0.25 | 6.04 |
| Stomach | 0.55 | 0.01 | 0.46 |
| Kidney | 2.79 | 7.00 | 17.37 |
| Urine * | 17.33 | 0.01 | 1.46 |
| Lung | 4.45 | 0.01 | 2.57 |
| Heart | 0.06 | 0.01 | 0.19 |
| Thyroid | 0.01 | 0.01 | 0.07 |
| Testis | 0.06 | 0.01 | 0.25 |
| Ovary | 0.02 | 0.01 | 0.09 |
| Muscle * | 0.03 | 0.01 | 0.06 |
| Femur * | 0.31 | 7.00 | 1.70 |
| Blood * | 0.12 | 0.01 | 0.09 |
* Unit (concentration) = %ID/g.